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Research

Primary papers and selected preprints behind the systems and claims tracked on this site.

2026 papersJSONBibTeXEvidence method
2026 · PNAS

Online supervised learning of temporal patterns in biological neural networks under feedback control

Sono et al. · Peer reviewed

Closed-loop modular cortical cultures learned to generate periodic and chaotic temporal signals.

DOI 10.1073/pnas.2521560123

2026 · Nature Biomedical Engineering

Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology

Liu et al. · Peer reviewed

A 3D organoid interface achieved near-complete surface coverage with 240 individually addressable microelectrodes.

DOI 10.1038/s41551-026-01620-y

2026 · Microsystems & Nanoengineering

Multilayered microelectrode array for monitoring electrophysiological signals of 3D neural networks in cerebral organoid

Kim et al. · Peer reviewed

Stacked mesh MEAs recorded depth-dependent activity across cerebral organoids for more than four weeks.

DOI 10.1038/s41378-026-01328-8

2026 · Cell Reports

Goal-directed learning in cortical organoids

Robbins et al. · Peer reviewed

Closed-loop cart-pole experiments with feedback-driven plasticity.

2026 · Nature Electronics

A three-dimensional micro-instrumented neural network device

Mritunjay, Sturm & Fu · Peer reviewed

3D flexible interface with chronic recording, stimulation and reservoir-computing experiments.

2026 · arXiv

Synthetic Biological Intelligence: System-Level Interaction Architectures, Interfaces, and Emerging Applications

Schottlender et al. · Preprint review

Systems-engineering survey of interfaces, encoding, decoding, feedback and benchmarking.

2025 · arXiv

Encoding Tactile Stimuli for Organoid Intelligence in Braille Recognition

Liu, Philamore & Ward-Cherrier · Preprint

Open-loop tactile encoding and classification with human forebrain organoids.

2025 · Patterns

Starting a Synthetic Biological Intelligence Lab from Scratch

Tanveer et al. · Peer reviewed

Practical overview of the multidisciplinary requirements for SBI experiments.

2024 · Frontiers in Artificial Intelligence

Open and remotely accessible Neuroplatform for research in wetware computing

Jordan et al. · Peer reviewed

Architecture and operation of FinalSpark’s remotely accessible organoid platform.

2024 · Advanced Science

Mind In Vitro Platforms: Versatile, Scalable, Robust, and Open Solutions for Interfacing With In Vitro Neural Networks

Zhang et al. · Peer reviewed

Open platform work aimed at reproducible living-neuron computing research.

2023 · Nature Electronics

Brain organoid reservoir computing for artificial intelligence

Cai et al. · Peer reviewed

Brainoware reservoir-computing experiments.

2023 · Frontiers in Science

Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish

Smirnova et al. · Perspective / framework

Field-defining organoid-intelligence framework and embedded-ethics proposal.

2022 · Neuron

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

Kagan et al. · Peer reviewed

DishBrain closed-loop Pong experiments.

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BIOCOMPUTERS 0.40 · 17 AUG 2026